Research Papers

Numerical simulation of near-field fluorescence correlation spectroscopy using a fiber probe

[+] Author Affiliations
Kazuo Kasahara, Toshiharu Saiki

Keio University, School of Integrated Design Engineering, 3-14-1 Hiyoshi, Yokohama, Kanagawa-Ken 211-0034 Japan

J. Nanophoton. 4(1), 043502 (January 26, 2010). doi:10.1117/1.3319569
History: Received October 12, 2009; Revised January 4, 2010; Accepted January 6, 2010; January 26, 2010; Online January 26, 2010
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Abstract

Numerical simulation of fluorescence correlation spectroscopy (FCS) based on near-field scanning optical microscopy (NSOM) was performed. A finite-difference time-domain method was employed to calculate the electric field distribution in the vicinity of the NSOM aperture and the Brownian motion of nanoparticles was reproduced by a Monte Carlo simulation. The physical validity of the simulation result was confirmed by comparing it with a theoretical calculation using a Gaussian observation volume, which is applied to FCS based on conventional optical microscopy.

© 2010 Society of Photo-Optical Instrumentation Engineers

Citation

Kazuo Kasahara and Toshiharu Saiki
"Numerical simulation of near-field fluorescence correlation spectroscopy using a fiber probe", J. Nanophoton. 4(1), 043502 (January 26, 2010). ; http://dx.doi.org/10.1117/1.3319569


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