Enhanced gold nanoshell scattering contrast using angled fiber probes

Vengadesan Nammalvar; Adrien Ming Jer Wang; Rebekah Anna Drezek

doi:10.1117/1.2741242

1 April 2007 Enhanced gold nanoshell scattering contrast using angled fiber probes

Vengadesan Nammalvar, Adrien Ming Jer Wang, Rebekah Anna Drezek

Author Affiliations +

Journal of Nanophotonics, Vol. 1, Issue 1, 013510 (April 2007). https://doi.org/10.1117/1.2741242

Abstract

Gold nanoshells are positioned to become a scattering-based contrast agent to improve the reflectance signals of nanoshell-targeted tissue. However, our study shows that a greater enhancement of nanoshell-induced reflectance signals can now be achieved when angularly oblique fiber geometries are used in place of the conventional orthogonal fiber geometry. This important finding was confirmed by conducting two experiments. First, diffuse reflectance spectra were collected from nanoshell-infused polystyrene phantoms at 0, 10, 20, 30 and 40 degree collection angles. At the 40 deg. fiber angle, the nanoshell-induced reflectance contrast, with respect to the native polystyrene phantom, is significantly increased. Based on these results, a reflectance study was then conducted for human cervical tissue treated with gold nanoshells at the 0 and 40 degree collection angles. Again, at the 40 deg. fiber angle, the signal level of the nanoshell-induced contrast in tissue is determined as statistically significant. Taken together, these results demonstrate that the use of the angularly oblique fiber geometry does significantly improve reflectance contrast.

Citation Download Citation

Vengadesan Nammalvar, Adrien Ming Jer Wang, and Rebekah Anna Drezek "Enhanced gold nanoshell scattering contrast using angled fiber probes," Journal of Nanophotonics 1(1), 013510 (1 April 2007). https://doi.org/10.1117/1.2741242

Published: 1 April 2007

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