Special Section on Nanoscale Morphology to Honor Russell Messier

Near-infrared luminescent nanomaterials for in-vivo optical imaging

[+] Author Affiliations
Peter K. Bachmann, Helga Hummel, Thomas Juestel, Jacqueline Merikhi, Cornelis R. Ronda, Volker Weiler

MIS, Philips Research Laboratories, Weisshausstrasse 2, Aachen, NRW 52066 Germany

J. Nanophoton. 2(1), 021920 (November 11, 2008). doi:10.1117/1.3039801
History: Received September 15, 2008; Revised November 8, 2008; Accepted November 10, 2008; November 11, 2008; Online November 11, 2008
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Abstract

Optical imaging using unspecific contrast agents as well as targeted and disease-specific agents play a vital role in preclinical research. Moreover, optical imaging is on the verge of establishing itself as a clinically relevant imaging modality. Also in-vitro diagnostical procedures rely to a large degree on optical labels to report disease-specific events. Materials that fulfill the basic requirements of this market are being used today, with cyanine dyes and semiconductor quantum dots being excellent examples. Other materials are being tested in laboratories throughout the world. Design rules suitable to develop new optical labels for in-vivo near-infrared optical imaging procedures have been formulated by us, and we have developed synthesis routes that lead to nano particles with small diameter, narrow size distribution, high quantum yield, and with stable surfaces required for bioconjugation to disease-specific ligands.

© 2008 Society of Photo-Optical Instrumentation Engineers

Citation

Peter K. Bachmann ; Helga Hummel ; Thomas Juestel ; Jacqueline Merikhi ; Cornelis R. Ronda, et al.
"Near-infrared luminescent nanomaterials for in-vivo optical imaging", J. Nanophoton. 2(1), 021920 (November 11, 2008). ; http://dx.doi.org/10.1117/1.3039801


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