Research Papers

Role of ZnS shell on stability, cytotoxicity, and photocytotoxicity of water-soluble CdSe semiconductor quantum dots surface modified with glutathione

[+] Author Affiliations
Salwa Ali Ibrahim, Tareq Youssef

Cairo University, National Institute of Laser Enhanced Sciences, 12613 Giza, Egypt

Wafaa Ahmed

Cairo University, National Cancer Institute, 11796 Cairo, Egypt

J. Nanophoton. 9(1), 093090 (Feb 24, 2015). doi:10.1117/1.JNP.9.093090
History: Received October 30, 2014; Accepted January 26, 2015
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Abstract.  The present study examines the stability and cytotoxicity of two quantum dots (QDs) systems in cell culture medium in the presence and absence of a thin layer of a ZnS shell. The two systems were built from a core, CdSe, and surface modified with glutathione (GSH), named CdSeGSH and CdSe/ZnSGSH. CdSe/ZnSGSHQDs exhibited a high photostability with a pronounced enhancement in photoluminescence in cell culture medium. Both systems showed insignificant reduction in cell viability of HFB-4 and MCF-7 cell lines in the dark. Following 60 min of low laser power exposure (irradiance of 10mWcm2), CdSeGSHQDs showed a remarkable decrease in cell viability, which may result from the detachment of GSH molecules, whereas CdSe/ZnSGSH QDs showed an insignificant decrease either immediately after irradiation or even 2 h post-exposure, which can be attributed to the high affinity between ZnS and GSH coatings. This study demonstrated that a thin layer of ZnS shell played a crucial role in the stability of CdSe/ZnSGSH QDs in cell culture medium with an improvement in luminescence efficiency, whereas surface modification with GSH molecules in the presence of ZnS showed no significant cytotoxic effects before or after photoirradiation, which makes this system attractive for several biomedical applications.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Salwa Ali Ibrahim ; Wafaa Ahmed and Tareq Youssef
"Role of ZnS shell on stability, cytotoxicity, and photocytotoxicity of water-soluble CdSe semiconductor quantum dots surface modified with glutathione", J. Nanophoton. 9(1), 093090 (Feb 24, 2015). ; http://dx.doi.org/10.1117/1.JNP.9.093090


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