A photonic crystal fiber based on surface plasmon resonance (PCF-SPR) sensing of a silver layer is investigated. The sensor has two advantages: polarization independence and less noble metal consumption. The coupling characteristics and sensing performance of the sensor are numerically investigated by the finite-element method employing the COMSOL Multiphysics® software. The optical loss spectrum of the PCF-SPR sensor can be easily tuned by varying the parameters of the structure. The defined amplitude sensitivity is and spectral sensitivity is corresponding to resolution of and , respectively.