Research Papers

Analysis and modeling of localized heat generation by tumor-targeted nanoparticles (Monte Carlo methods)

[+] Author Affiliations
Ehsan Sanattalab, Erhan Piskin

Hacettepe University, Beytepe campus, Chemical Engineering Department, Bioengineering Division, Lab 7, Ankara 06800, Turkey

Ahmad SalmanOgli

Hacettepe University, Beytepe campus, Chemical Engineering Department, Bioengineering Division, Lab 7, Ankara 06800, Turkey

Tabriz University, Electrical Engineering Department, Tabriz 51666, Iran

J. Nanophoton. 10(2), 026029 (Jun 20, 2016). doi:10.1117/1.JNP.10.026029
History: Received February 11, 2016; Accepted May 31, 2016
Text Size: A A A

Abstract.  We investigated the tumor-targeted nanoparticles that influence heat generation. We suppose that all nanoparticles are fully functionalized and can find the target using active targeting methods. Unlike the commonly used methods, such as chemotherapy and radiotherapy, the treatment procedure proposed in this study is purely noninvasive, which is considered to be a significant merit. It is found that the localized heat generation due to targeted nanoparticles is significantly higher than other areas. By engineering the optical properties of nanoparticles, including scattering, absorption coefficients, and asymmetry factor (cosine scattering angle), the heat generated in the tumor’s area reaches to such critical state that can burn the targeted tumor. The amount of heat generated by inserting smart agents, due to the surface Plasmon resonance, will be remarkably high. The light–matter interactions and trajectory of incident photon upon targeted tissues are simulated by MIE theory and Monte Carlo method, respectively. Monte Carlo method is a statistical one by which we can accurately probe the photon trajectories into a simulation area.

Figures in this Article
© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Ehsan Sanattalab ; Ahmad SalmanOgli and Erhan Piskin
"Analysis and modeling of localized heat generation by tumor-targeted nanoparticles (Monte Carlo methods)", J. Nanophoton. 10(2), 026029 (Jun 20, 2016). ; http://dx.doi.org/10.1117/1.JNP.10.026029


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.