Research Papers

Effects of graphene quantum dots on linear and nonlinear optical behavior of malignant ovarian cells

[+] Author Affiliations
Salman Mohajer, Mohammad Hossein Majles Ara

University of Kharazmi, Photonics Laboratory, Department of Physics, Mofatteh Street, Tehran 1571914911, Iran

Leila Serahatjoo

University of Kharazmi, Department of Bioscience, Mofatteh Street, Tehran 1571914911, Iran

J. Nanophoton. 10(3), 036014 (Aug 23, 2016). doi:10.1117/1.JNP.10.036014
History: Received May 25, 2016; Accepted August 8, 2016
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Abstract.  We investigate linear and nonlinear optical properties of standard human ovarian cancer cells (cell line: A2780cp) in vitro. Cells were treated by graphene quantum dots (GQDs) with two special concentrations. Nontoxicity of GQDs was examined in standard biological viability tests. Cancerous cells were fixed on a glass slide; then, interaction of light with biofilms was studied in linear and nonlinear regimes. Absorption spectra of untreated biofilms and biofilms with two different concentrations of GQDs was studied by UV-visible spectrophotometer. Optical behavior of biofilms in a linear regime of intensity (with low-intensity laser exposure) was reported using a simple optical setup. After that, we compared the attenuation of light in biofilm of cancerous cells with and without GQDs. Nonlinear behavior of these biofilms was investigated by a Z-scan setup using a continued wave He–Ne laser. Results showed that GQDs decreased the extinction coefficient and changed the sign and exact value of the nonlinear refractive index of malignant ovarian cells noticeably. The nonlinear refractive index of studied cells with no GQDs treatment was in the order of 108  (cm2/w) with a positive sign. This quantity changed to the same order of magnitude with a negative sign after GQDs treatment. Thus, GQDs can be used for cancer diagnosis under laser irradiation.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Salman Mohajer ; Mohammad Hossein Majles Ara and Leila Serahatjoo
"Effects of graphene quantum dots on linear and nonlinear optical behavior of malignant ovarian cells", J. Nanophoton. 10(3), 036014 (Aug 23, 2016). ; http://dx.doi.org/10.1117/1.JNP.10.036014


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