Long-term longitudinal monitoring of chemotherapy response using Spatial Frequency Domain Imaging using an improved two-layer Monte Carlo based inverse model (Conference Presentation)

Syeda Tabassum; Vivian E. Pera; Gage J. Greening; Timothy J. Muldoon; Darren M. Roblyer

doi:10.1117/12.2289293

14 March 2018 Long-term longitudinal monitoring of chemotherapy response using Spatial Frequency Domain Imaging using an improved two-layer Monte Carlo based inverse model (Conference Presentation)

Syeda Tabassum, Vivian E. Pera, Gage J. Greening, Timothy J. Muldoon, Darren M. Roblyer

Author Affiliations +

Proceedings Volume 10472, Diagnosis and Treatment of Diseases in the Breast and Reproductive System IV; 1047208 (2018) https://doi.org/10.1117/12.2289293
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Spatial Frequency Domain Imaging (SFDI) is a Diffuse Optical Imaging (DOI) technique that is well suited for preclinical functional imaging. Recently, we have shown that SFDI can successfully be used for longitudinal monitoring of a prostate subcutaneous tumor xenograft, where we have applied a look-up-table (LUT) based approach to extract tissue absorption (μa) and scattering properties (μs’). This LUT assumes a semi-infinite homogeneous medium and simulates reflectance (Rd) in spatial domain, and scales Rd for all μa and μs’ of interest from a single Monte Carlo simulation. However, converting Rd to spatial frequency domain (SFD) and scaling for μs’ may introduces unacceptable errors. Most importantly, the homogeneous model fails to mimic the actual physiology of a subcutaneous tumor, which can be described as a two-layer medium with a thin skin layer above the tumor layer. To overcome these limitations, we have developed a Monte Carlo based two-layer LUT with a wide range of tumor (bottom) layer optical properties, and fixed skin (top) properties. The two-layer LUT will be validated by two-layer silicone phantoms and tested for sensitivity to inaccurate layer assumptions. Additionally, the homogeneous and two-layer LUTs will be used on a large mouse tumor database (n=54 mice monitored over 3 months) to identify how the two-layer LUT can improve accuracy of SFDI by more accurately reflecting in vivo physiology, and reducing discretization and scaling errors. Improved SFDI findings in small animals, in the long run, will help establish clinical DOI tools for early detection of chemotherapy efficacy during treatment.

Conference Presentation

Citation Download Citation

Syeda Tabassum, Vivian E. Pera, Gage J. Greening, Timothy J. Muldoon, and Darren M. Roblyer "Long-term longitudinal monitoring of chemotherapy response using Spatial Frequency Domain Imaging using an improved two-layer Monte Carlo based inverse model (Conference Presentation)", Proc. SPIE 10472, Diagnosis and Treatment of Diseases in the Breast and Reproductive System IV, 1047208 (14 March 2018); https://doi.org/10.1117/12.2289293

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Tumors

Monte Carlo methods

Diffuse optical imaging

Physiology

Prostate

Skin

Absorption

Show All Keywords

Keywords/Phrases

Search In:

Publication Years