Colloidal lithography for trapping 10 nm enzymes

Adarsh Lalitha Ravindranath; Mirali Seyed Shariatdoust; Samuel Mathew; Reuven Gordon

doi:10.1117/12.2528394

9 September 2019 Colloidal lithography for trapping 10 nm enzymes

Adarsh Lalitha Ravindranath, Mirali Seyed Shariatdoust, Samuel Mathew, Reuven Gordon

Proceedings Volume 11083, Optical Trapping and Optical Micromanipulation XVI; 1108313 (2019) https://doi.org/10.1117/12.2528394
Event: SPIE Nanoscience + Engineering, 2019, San Diego, California, United States

Abstract

The single-beam gradient force optical tweezers have transformed various fields of scientific research by enabling manipulation and characterization of single molecules. Conventional optical tweezers pose limitations in trapping particles in the sub-Rayleigh regime. These limitations have been overcome with the help of plasmonic nanoapertures like the double-nanohole aperture. A modified colloidal lithography technique has been used in fabrication of double-nanohole apertures achieving dimensions appropriate for trapping single molecules in this regime. This paper demonstrates optical trapping of a single 10 nm enzyme, rubisco, using double-nanohole apertures fabricated using the modified colloidal lithography technique as well as presents the results from transmission characterization of different double-nanohole apertures carried out using the finite-difference time-domain (FDTD) simulations.

Conference Presentation

Citation Download Citation

Adarsh Lalitha Ravindranath, Mirali Seyed Shariatdoust, Samuel Mathew, and Reuven Gordon "Colloidal lithography for trapping 10 nm enzymes", Proc. SPIE 11083, Optical Trapping and Optical Micromanipulation XVI, 1108313 (9 September 2019); https://doi.org/10.1117/12.2528394

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