Particle sensing with confined optical field enhanced fluorescence emission (Conference Presentation)

Shamsul Abedin; Christian Vargas; Eric O. Potma

doi:10.1117/12.2545129

10 March 2020 Particle sensing with confined optical field enhanced fluorescence emission (Conference Presentation)

Shamsul Abedin, Christian Vargas, Eric O. Potma

Proceedings Volume 11257, Plasmonics in Biology and Medicine XVII; 112570P (2020) https://doi.org/10.1117/12.2545129
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

A surface plasmon resonance (SPR) based optical sensor is developed for real-time measurement of nano-scale binding events near a gold surface. The system, which we call confined optical field enhanced fluorescence emission (Cofefe), replaces the cw laser used in SPR devices by a femtosecond source, allowing for the generation and detection of optical non-linearities at the sensor surface. The binding events show up in the detector as diffraction limited spots against a dark background. We also demonstrate that the sensor can reliably register DNA hybridization adsorption events without any bright background or interference patterns that plague the traditional SPRI systems.

Conference Presentation

Citation Download Citation

Shamsul Abedin, Christian Vargas, and Eric O. Potma "Particle sensing with confined optical field enhanced fluorescence emission (Conference Presentation)", Proc. SPIE 11257, Plasmonics in Biology and Medicine XVII, 112570P (10 March 2020); https://doi.org/10.1117/12.2545129

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