Combined multiphoton microscopy and somatostatin receptor type 2 imaging of pancreatic neuroendocrine tumors

Noelle Daigle; Thomas G. Knapp; Suzann Duan; David W. Jones Jr.; Ali Azhdarinia; Sukhen C. Ghosh; Solmaz AghaAmiri; Naruhiko Ikoma; Jeannelyn Estrella; Martin J. Schnermann; Juanita L. Merchant; Travis W. Sawyer

doi:10.1117/12.2648113

6 March 2023 Combined multiphoton microscopy and somatostatin receptor type 2 imaging of pancreatic neuroendocrine tumors

Noelle Daigle, Thomas G. Knapp, Suzann Duan, David W. Jones Jr., Ali Azhdarinia, Sukhen C. Ghosh, Solmaz AghaAmiri, Naruhiko Ikoma, Jeannelyn Estrella, Martin J. Schnermann, Juanita L. Merchant, Travis W. Sawyer

Author Affiliations +

Proceedings Volume 12371, Multimodal Biomedical Imaging XVIII; 1237109 (2023) https://doi.org/10.1117/12.2648113
Event: SPIE BiOS, 2023, San Francisco, California, United States

Conference Poster

Abstract

Pancreatic neuroendocrine tumors (PNETs) are a rare but increasingly more prevalent cancer with heterogeneous clinical and pathological expression. Surgery is the preferred treatment for most PNETs, but existing intraoperative localization imaging techniques have poor tumor contrast and resolution. Our work tests the suitability of combined somatostatin receptor imaging (SRI) and multiphoton microscopy (MPM) for localizing PNETs, combining the labeled technique of SRI with the label-free technique of MPM for enhanced contrast and sensitivity. Our results suggest that this approach could be a valuable clinical tool for surgical localization and treatment of PNETs.

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Noelle Daigle, Thomas G. Knapp, Suzann Duan, David W. Jones Jr., Ali Azhdarinia, Sukhen C. Ghosh, Solmaz AghaAmiri, Naruhiko Ikoma, Jeannelyn Estrella, Martin J. Schnermann, Juanita L. Merchant, and Travis W. Sawyer "Combined multiphoton microscopy and somatostatin receptor type 2 imaging of pancreatic neuroendocrine tumors", Proc. SPIE 12371, Multimodal Biomedical Imaging XVIII, 1237109 (6 March 2023); https://doi.org/10.1117/12.2648113

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