Further characterization of photothermal breakdown products of uric acid stones following holmium:YAG laser lithotripsy

Randolph D. Glickman; Susan T. Weintraub; Neeru Kumar; Nicole S. Corbin; Omid Lesani; Joel M. H. Teichman M.D.

doi:10.1117/12.388040

13 June 2000 Further characterization of photothermal breakdown products of uric acid stones following holmium:YAG laser lithotripsy

Randolph D. Glickman, Susan T. Weintraub, Neeru Kumar, Nicole S. Corbin, Omid Lesani, Joel M. H. Teichman M.D.

Author Affiliations +

Proceedings Volume 3914, Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical; (2000) https://doi.org/10.1117/12.388040
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

Previously we found that Ho:YAG laser (2120 nm) lithotripsy of uric acid stones produced cyanide, a known thermal breakdown product of uric acid. We now report that alloxan, another thermal breakdown product, is also likely produced. Uric acid stones (approximately 98% pure) of human origin were placed in distilled water and subjected to one of the following experimental treatments: unexposed control, exposed to Ho:YAG laser, Nd:YAG laser, or mechanically crushed. Samples were then processed for HPLC analysis with UV detection. Peaks were identified by comparison to authentic standards. All samples contained uric acid, with retention time (RT) about 6 min. All of the laser-exposed samples contained a peak that eluted at 2.5 min, identical to the RT of authentic alloxan. Ho:YAG laser irradiation, however, produced a larger presumed alloxan peak than did the Nd:YAG laser. The peak at 2.5 min, as well as unidentified later-eluting peaks, were present in the laser-exposed, but not the unexposed or mechanically crushed, samples. These results confirm the thermal nature of lithotripsy performed with long-pulse IR lasers.

Citation Download Citation

Randolph D. Glickman, Susan T. Weintraub, Neeru Kumar, Nicole S. Corbin, Omid Lesani, and Joel M. H. Teichman M.D. "Further characterization of photothermal breakdown products of uric acid stones following holmium:YAG laser lithotripsy", Proc. SPIE 3914, Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical, (13 June 2000); https://doi.org/10.1117/12.388040

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