Synthesis and properties of quantum dots optical probes for bio-imaging

Tian-Cai Liu; Zhen-Li Huang; Hai-Qiao Wang; Yuan-Di Zhao; Qing-Ming Luo

doi:10.1117/12.667678

2 February 2006 Synthesis and properties of quantum dots optical probes for bio-imaging

Tian-Cai Liu, Zhen-Li Huang, Hai-Qiao Wang, Yuan-Di Zhao, Qing-Ming Luo

Proceedings Volume 6026, ICO20: Biomedical Optics; 60261I (2006) https://doi.org/10.1117/12.667678
Event: ICO20:Optical Devices and Instruments, 2005, Changchun, China

Abstract

A novel green synthesis of semiconductor nanoparticles was introduced and it was used as optical probes for bio-imaging. Quantum dots are known as <10nm scaled semiconductor nanoparticles, which could dramatically improve fluorescent imaging. Since these nanocrystals act as robust broadly tunable nano-emitters that can be excited by a single light source, they could pride significant advantages over current labels (e.g. traditional organic dyes, isotope and fluorescent proteins) in vitro and in vivo. As for a novel green synthesis, the usage of dangerous organic composites under rigorously air-free conditions was avoided, and ZnS-capped CdSe semiconductor nanoparticles was prepared economically. And the surface of as- synthesized nanoparticle would be modified by hydrophilic molecules for optical bio-probes. Moreover, such optical probes under aqueous biological conditions could maintain many characters: economy, photostability, colloidal stability, efficient fluorescence, low non-specific adsorption, biological compatibility and validity for multiplex assays.

Citation Download Citation

Tian-Cai Liu, Zhen-Li Huang, Hai-Qiao Wang, Yuan-Di Zhao, and Qing-Ming Luo "Synthesis and properties of quantum dots optical probes for bio-imaging", Proc. SPIE 6026, ICO20: Biomedical Optics, 60261I (2 February 2006); https://doi.org/10.1117/12.667678

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