Diagnostic potentialities of plasmon-resonant nanoparticles as contrast agents for the diffuse back scattering spectroscopy of biotissues

I. L. Maksimova; G. S. Terentyuk; E. A. Genina; A. A. Skaptsov; V. V. Tuchin; B. N. Khlebtsov; V. A. Bogatyrev; N. G. Khlebtsov

doi:10.1117/12.753447

20 June 2007 Diagnostic potentialities of plasmon-resonant nanoparticles as contrast agents for the diffuse back scattering spectroscopy of biotissues

I. L. Maksimova, G. S. Terentyuk, E. A. Genina, A. A. Skaptsov, V. V. Tuchin, B. N. Khlebtsov, V. A. Bogatyrev, N. G. Khlebtsov

Author Affiliations +

Proceedings Volume 6536, Saratov Fall Meeting 2006: Coherent Optics of Ordered and Random Media VII; 65360C (2007) https://doi.org/10.1117/12.753447
Event: Saratov Fall Meeting 2006, 2006, Saratov, Russian Federation

Abstract

The study is aimed at evaluation of diagnostic potential of plasmon-resonant nanoparticles as contrast agents for various techniques based on backward diffuse light scattering from biotissues. We consider the theoretical spectra of diffuse backscattering from a plane layer of gold nanospheres embedded into a plane layer of scattering dielectric spheres that mimic a strongly scattering sample of a biotissue. It is shown that the backscattering spectra contain information about 35-nm gold spheres provided the location depth is less than 600 mkm. The simulated color characteristics resemble the measured characteristics of a rat skin. The measured diffuse reflection spectra of 35-nm gold colloid are close to the spectra of 70/15-nm silica/gold nanoshells although the plasmon resonance wavelengths (520 and 630 nm) differ significantly.

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I. L. Maksimova, G. S. Terentyuk, E. A. Genina, A. A. Skaptsov, V. V. Tuchin, B. N. Khlebtsov, V. A. Bogatyrev, and N. G. Khlebtsov "Diagnostic potentialities of plasmon-resonant nanoparticles as contrast agents for the diffuse back scattering spectroscopy of biotissues", Proc. SPIE 6536, Saratov Fall Meeting 2006: Coherent Optics of Ordered and Random Media VII, 65360C (20 June 2007); https://doi.org/10.1117/12.753447

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