Laser welding of chitosan-GNRs films for the closure of a capsulorhexis

Francesca Rossi; Paolo Matteini; Fulvio Ratto; Luca Menabuoni M.D.; Ivo Lenzetti; Roberto Pini

doi:10.1117/12.876476

11 February 2011 Laser welding of chitosan-GNRs films for the closure of a capsulorhexis

Francesca Rossi, Paolo Matteini, Fulvio Ratto, Luca Menabuoni M.D., Ivo Lenzetti, Roberto Pini

Proceedings Volume 7885, Ophthalmic Technologies XXI; 78851O (2011) https://doi.org/10.1117/12.876476
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

In this work we present the first attempt to close the anterior lens capsule bag by the use of chitosan patches, where Gold Nanorods (GNRs) are embedded. GNRs exhibit intense localized plasmon resonances at optical frequencies in the near infrared (NIR): upon excitation with a NIR laser, a strong photothermal effect is produced, which can be exploited to develop minimally invasive therapies. Here we use the chitosan-GNRs films as a novel NIR sensitive nanocomposite for the photothermal conversion of NIR laser light during surgical interventions of tissue welding. Chitosan is an attractive biomaterial due to its biodegradability, biocompatibility, antimicrobial and wound healing-promoting activity. Colloidal GNRs were embedded in chitosan based, highly stabilized, flexible and easy-to-handle films, which were stored in water until the time of surgery. In these preliminary tests, a capsulorhexis was performed in freshly enucleated porcine eyes. The lens was aspired, then the patch was put onto the capsule bag and welded: a diode laser (810 nm) was used to deliver single spots (200 μm core diameter optical fiber) of local capsule/patch adhesion. Then the bag was refilled with silicon oil. The result is an immediate closure of the capsular tissue, with high mechanical strength. The laser welded chitosan- GNRs films are an innovative and highly stable solution to be exploited for the treatment of capsular breaks and for the implementation of a lens refilling procedure.

Citation Download Citation

Francesca Rossi, Paolo Matteini, Fulvio Ratto, Luca Menabuoni M.D., Ivo Lenzetti, and Roberto Pini "Laser welding of chitosan-GNRs films for the closure of a capsulorhexis", Proc. SPIE 7885, Ophthalmic Technologies XXI, 78851O (11 February 2011); https://doi.org/10.1117/12.876476

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