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Metal nanoparticles exhibit a large potential for the development of innovative and cost-effective sensing devices. They
fulfill key requirements for biosensors such as the potential for miniaturization as well as for high parallelization, and they
are compatible with the molecular world for the required biofunctionalization approaches. Their optical properties based on
the localized surface plasmon resonance (LSPR) are well adjustable from the UV- to the infrared spectral range using
chemical synthesis. Due to the strong influence of the surrounding dielectrics on the resonant properties these particles offer
a high potential for sensing of minimal changes in the surrounding media. Additionally, plasmon nanoparticles can induce a
local field-enhancement and so a signal amplification such as for fluorescence or Raman-spectroscopy. In general, plasmon
nanoparticles are well suited as label or as transducer for different optical detection techniques. We will give an overview
about recent developments in this field, and will present different sensing strategies at single particle or ensemble level and
based on planar or fiber-based systems aiming for ultrasensitive point-of care applications in bioanalytics.
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A. Csáki, K. Schröder, R. Willsch, H. Bartelt, W. Fritzsche, "Plasmonic nanoparticles for optical biosensing," Proc. SPIE 8073, Optical Sensors 2011; and Photonic Crystal Fibers V, 80730I (6 May 2011); https://doi.org/10.1117/12.886798