A porous silicon based microfluidic array for the optical monitoring of biomolecular interactions

Emanuele Orabona; Ilaria Rea; Ivo Rendina; Luca De Stefano III

doi:10.1117/12.887256

6 May 2011 A porous silicon based microfluidic array for the optical monitoring of biomolecular interactions

Emanuele Orabona, Ilaria Rea, Ivo Rendina, Luca De Stefano III

Proceedings Volume 8073, Optical Sensors 2011; and Photonic Crystal Fibers V; 807314 (2011) https://doi.org/10.1117/12.887256
Event: SPIE Optics + Optoelectronics, 2011, Prague, Czech Republic

Abstract

A porous silicon (PSi) based microarray has been integrated with a microfluidic system based on polydimethylsiloxane (PDMS) channels circuit, as a proof of concept device for the optical monitoring of selective label-free DNA-DNA interaction. Theoretical calculations, based on finite element method, taking into account molecular interactions, are in good agreement with the experimental results, and the developed numerical model can be used for device optimization. The functionalization process and the interaction between probe and target DNA has been monitored by spectroscopic reflectometry for each PSi element in the microchannels.

Citation Download Citation

Emanuele Orabona, Ilaria Rea, Ivo Rendina, and Luca De Stefano III "A porous silicon based microfluidic array for the optical monitoring of biomolecular interactions", Proc. SPIE 8073, Optical Sensors 2011; and Photonic Crystal Fibers V, 807314 (6 May 2011); https://doi.org/10.1117/12.887256

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available