Gold nanostructure-integrated silica-on-silicon waveguide for the detection of antibiotics in milk and milk products

Jayan Ozhikandathil; Simona Badilescu; Muthukumaran Packirisamy

doi:10.1117/12.2001473

24 October 2012 Gold nanostructure-integrated silica-on-silicon waveguide for the detection of antibiotics in milk and milk products

Jayan Ozhikandathil, Simona Badilescu, Muthukumaran Packirisamy

Author Affiliations +

Proceedings Volume 8412, Photonics North 2012; 84120W (2012) https://doi.org/10.1117/12.2001473
Event: Photonics North 2012, 2012, Montréal, Canada

Abstract

Antibiotics are extensively used in veterinary medicine for the treatment of infectious diseases. The use of antibiotics for the treatment of animals used for food production raised the concern of the public and a rapid screening method became necessary. A novel approach of detection of antibiotics in milk is reported in this work by using an immunoassay format and the Localized Surface Plasmon Resonance property of gold. An antibiotic from the penicillin family that is, ampicillin is used for testing. Gold nanostructures deposited on a glass substrate by a novel convective assembly method were heat-treated to form a nanoisland morphology. The Au nanostructures were functionalized and the corresponding antibody was absorbed from a solution. Solutions with known concentrations of antigen (antibiotics) were subsequently added and the spectral changes were monitored step by step. The Au LSPR band corresponding to the nano-island structure was found to be suitable for the detection of the antibody antigen interaction. The detection of the ampicillin was successfully demonstrated with the gold nano-islands deposited on glass substrate. This process was subsequently adapted for the integration of gold nanostructures on the silica-on-silicon waveguide for the purpose of detecting antibiotics.

Citation Download Citation

Jayan Ozhikandathil, Simona Badilescu, and Muthukumaran Packirisamy "Gold nanostructure-integrated silica-on-silicon waveguide for the detection of antibiotics in milk and milk products", Proc. SPIE 8412, Photonics North 2012, 84120W (24 October 2012); https://doi.org/10.1117/12.2001473

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