Dark-field microspectroscopic analysis of gold nanorods in spiral Ganglion neurons

J. Yong; W. G. A. Brown; K. Needham; B. A. Nayagam; A. Yu; S. L. McArthur; P. R. Stoddart

doi:10.1117/12.2033767

7 December 2013 Dark-field microspectroscopic analysis of gold nanorods in spiral Ganglion neurons

J. Yong, W. G. A. Brown, K. Needham, B. A. Nayagam, A. Yu, S. L. McArthur, P. R. Stoddart

Proceedings Volume 8923, Micro/Nano Materials, Devices, and Systems; 89234R (2013) https://doi.org/10.1117/12.2033767
Event: SPIE Micro+Nano Materials, Devices, and Applications, 2013, Melbourne, Victoria, Australia

Abstract

Heterogeneous samples of spiral ganglion neuron primary cells were incubated with gold nanorods in order to investigate the photothermal processes induced by exposure to 780 nm laser light. Dark-field microspectroscopy was used to analyze the distribution and spectrum of nanorods in the neurons. The scattering data showed a typical gold nanorod spectrum, while a shift in the peak position suggested changes in the refractive index of the nanorod environment. The relationship between gold nanorods distribution and local temperature has also been examined with an open pipette microelectrode placed in the surrounding bath of the neurons. These temperature measurements confirm that the gold nanorods provide efficient localized heating under 780 nm laser exposure.

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J. Yong, W. G. A. Brown, K. Needham, B. A. Nayagam, A. Yu, S. L. McArthur, and P. R. Stoddart "Dark-field microspectroscopic analysis of gold nanorods in spiral Ganglion neurons", Proc. SPIE 8923, Micro/Nano Materials, Devices, and Systems, 89234R (7 December 2013); https://doi.org/10.1117/12.2033767

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KEYWORDS

Nanorods

Gold

Neurons

Scattering

Light scattering

Nanoparticles

Temperature metrology

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