Spatial frequency domain imaging (SFDI) to quantify skin fibrosis in patients with scleroderma

Anahita Pilvar; Andreea Bujor; Darren Roblyer

doi:10.1117/12.2608182

7 March 2022 Spatial frequency domain imaging (SFDI) to quantify skin fibrosis in patients with scleroderma

Anahita Pilvar, Andreea Bujor, Darren Roblyer

Proceedings Volume PC11934, Photonics in Dermatology and Plastic Surgery 2022; PC1193402 (2022) https://doi.org/10.1117/12.2608182
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

The extend of skin fibrosis in scleroderma patients is currently assessed using the semi-quantitative modified Rodnan skin score (mRSS) which is an assessment of skin thickness. We investigated the use of spatial frequency domain imaging (SFDI) for more quantitative and reliable assessment of skin fibrosis. SFDI measurements were conducted at 6 body locations of 10 control subjects and 10 patients with scleroderma. SFDI results, especially reduced scattering coefficient, show strong correlation with the mRSS score measured by the physician at the same body locations suggesting that SFDI is a reliable tool to quantify skin fibrosis in scleroderma patients.

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Citation Download Citation

Anahita Pilvar, Andreea Bujor, and Darren Roblyer "Spatial frequency domain imaging (SFDI) to quantify skin fibrosis in patients with scleroderma", Proc. SPIE PC11934, Photonics in Dermatology and Plastic Surgery 2022, PC1193402 (7 March 2022); https://doi.org/10.1117/12.2608182

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KEYWORDS

Skin

Biopsy

Collagen

Tissue optics

Gold

Modulation

Optical properties

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