Spatial frequency domain imaging (SFDI) for the assessment of disease progression in scleroderma

Aarohi Mehendale; Anahita Pilvar; Kavon Karrobi; Hung Vo; Andreea Bujor; Darren M. Roblyer

doi:10.1117/12.2691937

13 March 2024 Spatial frequency domain imaging (SFDI) for the assessment of disease progression in scleroderma

Aarohi Mehendale, Anahita Pilvar, Kavon Karrobi, Hung Vo, Andreea Bujor, Darren M. Roblyer

Proceedings Volume PC12816, Photonics in Dermatology and Plastic Surgery 2024; PC128160B (2024) https://doi.org/10.1117/12.2691937
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Scleroderma, or systemic sclerosis (SSc) is a chronic, autoimmune disorder that manifests in the fibrosis of skin and internal organs. The clinical gold standard used to track SSc disease progression is the modified Rodnan skin score (mRSS), which is based on clinical palpation. Spatial Frequency Domain Imaging (SFDI), a widefield, non-contact diffuse optical imaging technology may provide an alternate quantitative and objective method to track progression of SSc by measuring tissue reflectance and optical properties. To investigate this, SFDI measurements were conducted on 10 SSc patients and 8 healthy controls, with 6 patients and 2 controls also being measured longitudinally. We found that there were proportional changes in SFDI metrics (μs' at 851 nm and Rd at 851 nm and 0.2 mm-1) corresponding to SSc progression (measured by mRSS scores and with histopathological metrics), suggesting SFDI could provide an improved method to track SSc progression.

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Citation Download Citation

Aarohi Mehendale, Anahita Pilvar, Kavon Karrobi, Hung Vo, Andreea Bujor, and Darren M. Roblyer "Spatial frequency domain imaging (SFDI) for the assessment of disease progression in scleroderma", Proc. SPIE PC12816, Photonics in Dermatology and Plastic Surgery 2024, PC128160B (13 March 2024); https://doi.org/10.1117/12.2691937

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KEYWORDS

Diseases and disorders

Skin

Control systems

Diffuse optical imaging

Tissues

Histopathology

Optical properties

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