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Commercial imaging systems such as mobile phones are suitable for fluorescence detection of in vivo and ex vivo tissue samples. To leverage this potential, a uniform plane of excitation light is necessary to make quantitative measurements of regions within an image. We have developed a computational model to simulate the illumination of an arbitrary number of sources. Using a pattern search algorithm, the position of these sources can be determined to generate a uniform plane of excitation light. Initial studies demonstrate that 4 fiber optic sources can be used to generate uniform illumination for biopsy samples with different geometries.
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Riley Deutsch, Roujia Wang, Brian T. Crouch, Nimmi Ramanujam, "Development of a fluorescence illumination optimization algorithm for mobile imaging applications in resource limited settings," Proc. SPIE PC11950, Optics and Biophotonics in Low-Resource Settings VIII, PC1195006 (7 March 2022); https://doi.org/10.1117/12.2609801