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2 March 2022 Time-lapse Brillouin imaging of the neural tube closure in chick embryo
Chenchen Handler, Jitao Zhang, Giuliano Scarcelli
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Proceedings Volume PC11962, Optical Elastography and Tissue Biomechanics VIV; PC1196207 (2022) https://doi.org/10.1117/12.2610683
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
Neural tube closure, or neurulation, has been studied across a range of vertebrates as it is the basis of embryonic development. Closure failure can lead to severe congenital malformations. Current technologies require fixed specimens and physical contact to extract a modulus. Here we investigate the mechanical changes of the neural plate from formation to closure within intact live chick embryos using time-lapse Brillouin imaging and ex-ovo culture. We observed an increase in the Brillouin modulus of the neural plate as the embryo develops in ex-ovo culture. By quantifying the timing and the extent of the forces that drive neural tube closure, we can more accurately identify when and why neural tube defects occur.
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Chenchen Handler, Jitao Zhang, and Giuliano Scarcelli "Time-lapse Brillouin imaging of the neural tube closure in chick embryo", Proc. SPIE PC11962, Optical Elastography and Tissue Biomechanics VIV, PC1196207 (2 March 2022); https://doi.org/10.1117/12.2610683
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KEYWORDS
Atomic force microscopy
Mechanics
Organisms
Tissues
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