Bond-selective full-field optical coherence tomography

Haonan Zong; Celalettin Yurdakul; Jian Zhao; Zian Wang; Fukai Chen; M. Selim Ünlü; Ji-Xin Cheng

doi:10.1117/12.2652645

9 March 2023 Bond-selective full-field optical coherence tomography

Haonan Zong, Celalettin Yurdakul, Jian Zhao, Zian Wang, Fukai Chen, M. Selim Ünlü, Ji-Xin Cheng

Author Affiliations +

Proceedings Volume PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII; PC123670X (2023) https://doi.org/10.1117/12.2652645
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Optical coherence tomography (OCT) has been a powerful 3D optical imaging tool in the last decade while it lacks molecular information. In this work, we integrate the mid-infrared photothermal microscopy with the OCT approach to demonstrate a bond-selective full-field optical coherence tomography (BS-FF-OCT), in which a pulsed mid-infrared laser is used to modulate the full-field OCT signal through the photothermal effect. This method achieves label-free volumetric infrared spectroscopic imaging at 1-μm isotropic resolution, demonstrated by a variety of samples, including 1 μm PMMA beads embedded in agarose gel, polypropylene fiber mattress, myelinated nerve bundle in mouse brain tissue, Caenorhabditis elegans, and cancer cell spheroids.

Conference Presentation

Citation Download Citation

Haonan Zong, Celalettin Yurdakul, Jian Zhao, Zian Wang, Fukai Chen, M. Selim Ünlü, and Ji-Xin Cheng "Bond-selective full-field optical coherence tomography", Proc. SPIE PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII, PC123670X (9 March 2023); https://doi.org/10.1117/12.2652645

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