Vaginal hemodynamic changes during sexual arousal in a rat model by diffuse optical spectroscopy (Conference Presentation)

Hyeryun Jeong; Myeongsu Seong; Hyun-Suk Lee; Kwangsung Park; Jae Gwan Kim

doi:10.1117/12.2252061

19 April 2017 Vaginal hemodynamic changes during sexual arousal in a rat model by diffuse optical spectroscopy (Conference Presentation)

Hyeryun Jeong, Myeongsu Seong, Hyun-Suk Lee, Kwangsung Park, Jae Gwan Kim

Author Affiliations +

Proceedings Volume 10038, Therapeutics and Diagnostics in Urology: Lasers, Robotics, Minimally Invasive, and Advanced Biomedical Devices; 100380M (2017) https://doi.org/10.1117/12.2252061
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Not only men suffer from sexual dysfunction, but the number of women who have sexual dysfunction rises. Therefore, it is necessary to develop an objective diagnostic technique to examine the sexual dysfunction of female patients, who are afflicted with the disorders. For this purpose, we developed a diffuse optical spectroscopy (DOS) probe to measure the change of oxy-, deoxy-, and total hemoglobin concentration along with blood flow from vaginal wall of female rats. A cylindrical stainless steel DOS probe with a diameter of 3 mm was designed for the vaginal wall of rats which consisted of two lasers (785 and 850nm) and two spectrometers with a separation of 2 mm. A thermistor was placed on the top of the probe to measure the temperature change from vaginal wall during experiments. A modified Beer-Lambert’s law is utilized to acquire the changes of oxy-, deoxy-, and total hemoglobin, and blood flow information is obtained by diffuse speckle contrast analysis technique. For the experiments, Sprague Dawley (~400 g) female rats were divided into two groups (control and vaginal dryness model). Vaginal oxygenation, blood flow and temperature were continuously monitored before and after sexual around induced by apomorphine. After the measurement, histologic examination was performed to support the results from DOS probe in the vaginal wall. The hemodynamic information acquired by the DOS probe can be utilized to establish an objective and accurate standard of the female sexual disorders.

Conference Presentation

Citation Download Citation

Hyeryun Jeong, Myeongsu Seong, Hyun-Suk Lee, Kwangsung Park, and Jae Gwan Kim "Vaginal hemodynamic changes during sexual arousal in a rat model by diffuse optical spectroscopy (Conference Presentation)", Proc. SPIE 10038, Therapeutics and Diagnostics in Urology: Lasers, Robotics, Minimally Invasive, and Advanced Biomedical Devices, 100380M (19 April 2017); https://doi.org/10.1117/12.2252061

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KEYWORDS

Blood circulation

Diffuse optical spectroscopy

Hemodynamics

Temperature metrology

Diagnostics

Speckle

Spectrometers

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