Nanoscale patterning of biopolymers for controlled microfluidic behavior and drug release (Conference Presentation)

Akshit Peer; Rabin Dhakal; Rana Biswas; Jaeyoun Kim

doi:10.1117/12.2253246

24 April 2017 Nanoscale patterning of biopolymers for controlled microfluidic behavior and drug release (Conference Presentation)

Akshit Peer, Rabin Dhakal, Rana Biswas, Jaeyoun Kim

Author Affiliations +

Proceedings Volume 10061, Microfluidics, BioMEMS, and Medical Microsystems XV; 100610B (2017) https://doi.org/10.1117/12.2253246
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

It is of great interest to pattern biomaterials on the nanoscale and microscale to control diverse biomedical functions. We utilize soft lithographic technique to nanopattern poly (L-lactic acid) (PLLA) - a biodegradable and biocompatible polymer. We find that the PLLA surfaces nanopatterned with 750 nm pitch nanocup or nanocone arrays exhibit drug release rates 25-30% lower than that of the flat surface, which is counter-intuitive given the nanopattern-induced increase in their surface areas. Based on diffusion and microfluidic meniscus curvature minimization analyses, we attribute the decreased drug release rate to the incomplete wetting of the nanopatterned surface by the fluid.

Conference Presentation

Citation Download Citation

Akshit Peer, Rabin Dhakal, Rana Biswas, and Jaeyoun Kim "Nanoscale patterning of biopolymers for controlled microfluidic behavior and drug release (Conference Presentation)", Proc. SPIE 10061, Microfluidics, BioMEMS, and Medical Microsystems XV, 100610B (24 April 2017); https://doi.org/10.1117/12.2253246

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