Laserthermia And New PDT In Neurosurgery

T. Sakai; I. Fujishima; K. Sugiyama

doi:10.1117/12.952056

11 September 1989 Laserthermia And New PDT In Neurosurgery

T. Sakai, I. Fujishima, K. Sugiyama

Proceedings Volume 1066, Laser Surgery: Advanced Characterization, Therapeutics, and Systems; (1989) https://doi.org/10.1117/12.952056
Event: OE/LASE '89, 1989, Los Angeles, CA, United States

Abstract

The usefulness of laserthermia using Nd:YAG laser was studied experimentally and clinically to treat deep seated brain tumor. Histological changes, temperature profile, modification of blood-brain barrier (BBB) were studied. Five patients with brain tumors were treated with laserthermia. Laserthermia using Nd:YAG laser is easy and safe to use and it is beneficial to treat deep seated brain tumor. Photodynamic therapy (PDT) was also evaluated using the photosensitizing agent pheophorbide-a (Ph-a) and an acoustic Q switched Nd:YAG laser. In xitro survival of T98G human glioma cells pretreated with Ph-a (1x10^-3 mole/1 in albumin) and irradiated with a pulsed Nd:YAG laser for 5 minutes at 37.0°C was 0.4%. The present study suggested that PDT using an acoustic Q switched Nd:YAG laser and Ph-a was useful in treating experimental human glioma.

Citation Download Citation

T. Sakai, I. Fujishima, and K. Sugiyama "Laserthermia And New PDT In Neurosurgery", Proc. SPIE 1066, Laser Surgery: Advanced Characterization, Therapeutics, and Systems, (11 September 1989); https://doi.org/10.1117/12.952056

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available