Water and lipid contents measured at various parts of the human body with a six-wavelength time-resolved spectroscopy system

Hiroaki Suzuki; Etsuko Ohmae; Kenji Yoshimoto; Hiroko Wada; Shu Homma; Norihiro Suzuki; Tetsuya Mimura; Yutaka Yamashita; Yukio Ueda

doi:10.1117/12.2507429

1 March 2019 Water and lipid contents measured at various parts of the human body with a six-wavelength time-resolved spectroscopy system

Hiroaki Suzuki, Etsuko Ohmae, Kenji Yoshimoto, Hiroko Wada, Shu Homma, Norihiro Suzuki, Tetsuya Mimura, Yutaka Yamashita, Yukio Ueda

Author Affiliations +

Proceedings Volume 10874, Optical Tomography and Spectroscopy of Tissue XIII; 108740A (2019) https://doi.org/10.1117/12.2507429
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Time-domain (TD) near-infrared spectroscopy (NIRS) is an effective method of quantifying optical and biological properties, such as the mean optical path length, absorption coefficient, reduced scattering coefficient, and oxyhemoglobin and deoxy-hemoglobin concentrations of biological tissues. In addition to these parameters, water and lipid contents are important biological parameters expected to be useful information in clinical application. For our previous TD-NIRS systems, we used three wavelengths (760, 800, and 830 nm) that are sensitive to oxy- and deoxy-hemoglobin. To quantitatively measure water and lipid contents of biological tissues, we developed a new TD-NIRS system with three additional wavelengths (908, 936, and 976 nm) that are sensitive to water and lipids. The new six-wavelength TDNIRS system comprises six-wavelength pulsed light sources, two types of photomultiplier tubes (GaAs and InGaAs PMTs), a time-correlated single-photon counting unit, and optical fiber bundles. In this pilot study, we present the measurement results of oxy- and deoxy-hemoglobin concentrations, tissue oxygen saturation, and water and lipid contents at the calf, forearm, and abdomen of five healthy adult volunteers in a resting state using the six-wavelength TD-NIRS system. We thus confirmed that the fat thickness measured by ultrasonography and the water content measured by the six-wavelength TD-NIRS system were negatively correlated, whereas the fat thickness and lipid content were positively correlated. We expect that the six-wavelength TD-NIRS system will be used in clinical studies as a point-of-care testing device for the bedside monitoring of human subjects.

Conference Presentation

Citation Download Citation

Hiroaki Suzuki, Etsuko Ohmae, Kenji Yoshimoto, Hiroko Wada, Shu Homma, Norihiro Suzuki, Tetsuya Mimura, Yutaka Yamashita, and Yukio Ueda "Water and lipid contents measured at various parts of the human body with a six-wavelength time-resolved spectroscopy system", Proc. SPIE 10874, Optical Tomography and Spectroscopy of Tissue XIII, 108740A (1 March 2019); https://doi.org/10.1117/12.2507429

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available