Nano-bio interactions as characterized by SERS: The interaction of liposomes with gold nanostructures is highly dependent on lipid composition and charge

Vesna Živanović; Janina Kneipp

doi:10.1117/12.2508584

7 March 2019 Nano-bio interactions as characterized by SERS: The interaction of liposomes with gold nanostructures is highly dependent on lipid composition and charge

Vesna Živanović, Janina Kneipp

Author Affiliations +

Proceedings Volume 10894, Plasmonics in Biology and Medicine XVI; 1089404 (2019) https://doi.org/10.1117/12.2508584
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Understanding how gold nanoparticles interact with liposomes is important for biotechnology and drug delivery. The characterization of liposome structure and composition using gold nanoparticles by surface-enhanced Raman scattering (SERS) has show that the composition of the lipid bilayers influences the interaction of the gold nanoparticles with the lipid structures. Here, vesicles composed of phosphatidylcholine, sphingomyelin, and cholesterol in different proportions reveal that very small changes in the lipid composition can alter the contact between liposomes and gold nanostructures. The SERS spectra of phosphatidylcholine and phosphatidylcholine / cholesterol liposomes indicate that cholesterol has strong effects on the contacts of the vesicles with the nanoparticles. Moreover, the interaction of citrate-stabilized gold nanoparticles varies depending on the preparation protocol, and the presence of organic solvent during preparation of the gold nanoparticle-liposome composites. In a model system where the charge of the lipid bilayers is varied, the influence of negative charge of the lipids on liposome structure and their contact with the nanoparticles is discussed. The results have implications for the development of new gold nanoparticle and gold nanoparticle-liposome-based drug delivery systems.

Citation Download Citation

Vesna Živanović and Janina Kneipp "Nano-bio interactions as characterized by SERS: The interaction of liposomes with gold nanostructures is highly dependent on lipid composition and charge", Proc. SPIE 10894, Plasmonics in Biology and Medicine XVI, 1089404 (7 March 2019); https://doi.org/10.1117/12.2508584

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