Pixel-wise modified Beer-Lambert model for intraoperative functional brain mapping

Charly Caredda; Laurent Mahieu-Williame; Raphaël Sablong; Michaël Sdika; Jacques Guyotat; Bruno Montcel

doi:10.1117/12.2527045

19 July 2019 Pixel-wise modified Beer-Lambert model for intraoperative functional brain mapping

Charly Caredda, Laurent Mahieu-Williame, Raphaël Sablong, Michaël Sdika, Jacques Guyotat, Bruno Montcel

Proceedings Volume 11073, Clinical and Preclinical Optical Diagnostics II; 1107317 (2019) https://doi.org/10.1117/12.2527045
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

A RGB camera and a continuous wave white light illumination is a suitable approach to intraoperatively localize the sensory and motor areas of the patient brain. The analysis of the reflectance spectra through the modified Beer-Lambert law enables us to measure the concentration changes of oxygenated and deoxygenated hemoglobin during the video acquisition. However these concentration changes depend on the wavelength dependent optical mean path length. A manual image segmentation and Monte-Carlo simulations allow us to precisely choose the mean path length in a pixel-wise manner.

Citation Download Citation

Charly Caredda, Laurent Mahieu-Williame, Raphaël Sablong, Michaël Sdika, Jacques Guyotat, and Bruno Montcel "Pixel-wise modified Beer-Lambert model for intraoperative functional brain mapping", Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II, 1107317 (19 July 2019); https://doi.org/10.1117/12.2527045

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