Frequency multiplexed intensity modulated diffuse reflectance system for quantification of tissue and arterial oxygen saturation

Po-Jian Liang; Sheng-Hao Tseng

doi:10.1117/12.2526611

11 July 2019 Frequency multiplexed intensity modulated diffuse reflectance system for quantification of tissue and arterial oxygen saturation

Po-Jian Liang, Sheng-Hao Tseng

Author Affiliations +

Proceedings Volume 11074, Diffuse Optical Spectroscopy and Imaging VII; 110742H (2019) https://doi.org/10.1117/12.2526611
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

Pulse oximeter has been a widely used instrument in hospitals or household for measuring arterial oxygen saturation value. Its annual global market value has exceeded USD 1 billion and is still growing. There are two main shortcomings in most pulse oximeters on the market: 1. database based algorithm limits the range of precision, and 2. incapable of measuring tissue oxygen saturation related to local tissue oxygen exchange condition. We developed a 3-wavelength frequency multiplexed intensity modulated diffuse reflectance system in which the modulation frequencies of the 3 light sources are different so that the light reflectance at the 3 wavelengths can be collected by the detector simultaneously. This allows us achieving determination of absorption and reduced scattering coefficients at the 3 wavelengths of the exactly same instant of time and this can lead to accurate quantification of tissue and arterial oxygen saturations. This technique works in conjunction with a photon diffusion equation and does not need to build a database in advance to calculate arterial oxygen saturation. In addition, capability of this system in measuring tissue oxygen saturation would facilitate swift monitoring of local tissue blood circulation.

Citation Download Citation

Po-Jian Liang and Sheng-Hao Tseng "Frequency multiplexed intensity modulated diffuse reflectance system for quantification of tissue and arterial oxygen saturation", Proc. SPIE 11074, Diffuse Optical Spectroscopy and Imaging VII, 110742H (11 July 2019); https://doi.org/10.1117/12.2526611

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KEYWORDS

Oxygen

Tissues

Absorption

Modulation

Diffuse reflectance spectroscopy

Multiplexing

Oximeters

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