Uptake study of gold nanoparticles into cancer cells using high-order image correlation spectroscopy

D. Katoozi; A. H. A. Clayton; D. J. Moss; J. W. M. Chon

doi:10.1117/12.2547985

31 December 2019 Uptake study of gold nanoparticles into cancer cells using high-order image correlation spectroscopy

D. Katoozi, A. H. A. Clayton, D. J. Moss, J. W. M. Chon

Proceedings Volume 11201, SPIE Micro + Nano Materials, Devices, and Applications 2019; 112011Y (2019) https://doi.org/10.1117/12.2547985
Event: ANZCOP, 2019, Melbourne, Australia

Abstract

Gold nanoparticles (AuNPs), due to unique optical properties and has become excellent tools for cancer diagnosis and therapy. Various techniques are used to get information about AuNPs cellar uptake and aggregation, however; these methods are not suitable for live cell imaging. Here we used non-destructive characterisation method namely High order Image Correlation Spectroscopy (HICS) combined with Dark Field Microscopy (DFM) is used to get information about cellular uptake and aggregation of 80 nm gold nanosphere (AuNSs) inside HeLa cell. Results confirm the accuracy and simple nature of the proposed method for future live-cell imaging.

Citation Download Citation

D. Katoozi, A. H. A. Clayton, D. J. Moss, and J. W. M. Chon "Uptake study of gold nanoparticles into cancer cells using high-order image correlation spectroscopy", Proc. SPIE 11201, SPIE Micro + Nano Materials, Devices, and Applications 2019, 112011Y (31 December 2019); https://doi.org/10.1117/12.2547985

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