In vivo diagnosis of idiopathic pulmonary fibrosis (IPF) using endobronchial OCT (Conference Presentation)

Sreyankar Nandy; Benjamin W. Roop; David C. Adams; Ashok Muniappan; Colleen M. Keyes; John C. Wain; Christopher R. Morse; Michael Lanuti; Thomas V. Colby; Angela Shih; Mari Mino-Kenudson; Eugene J. Mark; Richard L. Kradin; Amita Sharma; Lloyd Liang; Diane L. Davies; Margit V. Szabari; Andrew M. Tager; Melissa J. Suter; Lida P. Hariri

doi:10.1117/12.2541981

6 March 2020 In vivo diagnosis of idiopathic pulmonary fibrosis (IPF) using endobronchial OCT (Conference Presentation)

Sreyankar Nandy, Benjamin W. Roop, David C. Adams, Ashok Muniappan, Colleen M. Keyes, John C. Wain, Christopher R. Morse, Michael Lanuti, Thomas V. Colby, Angela Shih, Mari Mino-Kenudson, Eugene J. Mark, Richard L. Kradin, Amita Sharma, Lloyd Liang, Diane L. Davies, Margit V. Szabari, Andrew M. Tager, Melissa J. Suter, Lida P. Hariri

Author Affiliations +

Proceedings Volume 11214, Endoscopic Microscopy XV; 112140B (2020) https://doi.org/10.1117/12.2541981
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive form of interstitial lung disease (ILD). High-resolution CT (HRCT) is currently used to identify macroscopic IPF features. However, for 50% of patients, ultimate diagnosis relies on microscopic features from invasive, high-risk surgical biopsies (SLBX). We conducted a pilot study to assess endobronchial OCT (EB-OCT) for in vivo diagnosis of IPF, enrolling ILD patients with nondiagnostic HRCT undergoing SLBX. EB-OCT visualized salient IPF features, including microscopic features not visible on HRCT, and accurately diagnosed IPF and non-IPF ILD as compared with SLBX. EB-OCT has the potential for in vivo microscopic diagnosis of IPF.

Conference Presentation

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Sreyankar Nandy, Benjamin W. Roop, David C. Adams, Ashok Muniappan, Colleen M. Keyes, John C. Wain, Christopher R. Morse, Michael Lanuti, Thomas V. Colby, Angela Shih, Mari Mino-Kenudson, Eugene J. Mark, Richard L. Kradin, Amita Sharma, Lloyd Liang, Diane L. Davies, Margit V. Szabari, Andrew M. Tager, Melissa J. Suter, and Lida P. Hariri "In vivo diagnosis of idiopathic pulmonary fibrosis (IPF) using endobronchial OCT (Conference Presentation)", Proc. SPIE 11214, Endoscopic Microscopy XV, 112140B (6 March 2020); https://doi.org/10.1117/12.2541981

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