Optical study of the structural alteration in hippocampal tissues in chronic stress using partial wave spectroscopy (Conference Presentation)

Prabhakar Pradhan; Pradeep K. Shukla; Shiva Bhandari; Prakash Adhikari; Radhakrishna Rao

doi:10.1117/12.2547162

9 March 2020 Optical study of the structural alteration in hippocampal tissues in chronic stress using partial wave spectroscopy (Conference Presentation)

Prabhakar Pradhan, Pradeep K. Shukla, Shiva Bhandari, Prakash Adhikari, Radhakrishna Rao

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Proceedings Volume 11226, Neural Imaging and Sensing 2020; 112261I (2020) https://doi.org/10.1117/12.2547162
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

We report mesoscopic physics based nanoscale sensitive partial wave spectroscopy (PWS) study of the structural changes in brain hippocampal region due to chronic stress induced by a stress hormone in a mouse model. Our results show that the change in the average degree of structural disorder in hippocampal tissues from stressed hormone induced mice brains has a higher structural disorder value relative to that of controlled mice, and the change is in correlation with the duration of the stress. Furthermore, the structural changes are peaked around the mid hippocampal regions, both sides of the hippocampal tissues centering around the ventricle.

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Prabhakar Pradhan, Pradeep K. Shukla, Shiva Bhandari, Prakash Adhikari, and Radhakrishna Rao "Optical study of the structural alteration in hippocampal tissues in chronic stress using partial wave spectroscopy (Conference Presentation)", Proc. SPIE 11226, Neural Imaging and Sensing 2020, 112261I (9 March 2020); https://doi.org/10.1117/12.2547162

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KEYWORDS

Tissues

Brain

Spectroscopy

Tissue optics

Biomedical optics

Mouse models

Receptors

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