Label-free multi-modal multiphoton imaging for real-time point-of-procedure assessment of core-needle and fine-needle biopsy specimens (Conference Presentation)

Lingxiao Yang; Yi Sun; Darold R. Spillman Jr.; Sixian You; Stephen A. Boppart

doi:10.1117/12.2543216

9 March 2020 Label-free multi-modal multiphoton imaging for real-time point-of-procedure assessment of core-needle and fine-needle biopsy specimens (Conference Presentation)

Lingxiao Yang, Yi Sun, Darold R. Spillman Jr., Sixian You, Stephen A. Boppart

Author Affiliations +

Proceedings Volume 11234, Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis; 112340X (2020) https://doi.org/10.1117/12.2543216
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Label-free multiphoton imaging has been a powerful tool to study the microstructure and specific chemical distributions in biological tissue, especially in tumors and their microenvironments. Thus, this technique has great potential to assist in cancer-related clinical studies. A portable label-free multiphoton imaging system was constructed with four imaging modalities: two- and three- photon fluorescence, and second and third harmonic generation. Mosaicked multimodal images can be acquired with dual-channel detection and galvo-mirror scanning. This system was demonstrated during animal surgeries for real-time, label-free assessment of tumor tissue samples acquired via core-needle biopsy and fine-needle aspiration.

Conference Presentation

Citation Download Citation

Lingxiao Yang, Yi Sun, Darold R. Spillman Jr., Sixian You, and Stephen A. Boppart "Label-free multi-modal multiphoton imaging for real-time point-of-procedure assessment of core-needle and fine-needle biopsy specimens (Conference Presentation)", Proc. SPIE 11234, Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 112340X (9 March 2020); https://doi.org/10.1117/12.2543216

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