A multi-channel diffuse correlation spectroscopy system for dynamic topography of blood flow index in deep tissues

Jinbin Xie M.D.; Xiangdong He M.D.; Zhuanping Qin; Feng Gao

doi:10.1117/12.2541810

21 February 2020 A multi-channel diffuse correlation spectroscopy system for dynamic topography of blood flow index in deep tissues

Jinbin Xie M.D., Xiangdong He M.D., Zhuanping Qin, Feng Gao

Author Affiliations +

Proceedings Volume 11234, Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis; 112341K (2020) https://doi.org/10.1117/12.2541810
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Near-infrared (NIR) diffuse correlation spectroscopy (DCS) provides a novel tool for clinical blood flow monitoring. Although DCS has the advantages of non-invasiveness, high sensitivity and large penetration depth, increasing its acquisition speed to achieve real-time imaging is still an on-going task. In this work, we propose a multi-channel DCS system for dynamic topography of blood flow index in deep tissues, where a dynamic nature up to one frame per second is implemented by combining the concurrency of FPGA-based 10 channel hardware correlators of multi-τ -design and NIR-sensitive avalanche photodiode detectors. The flow-velocity resolution, measurement fidelity and imaging depth of the system were evaluated by phantom experiments. In vivo experiments on human arm were then performed that accurately imaged the shape and position of the blood vessels and demonstrated the ability of the proposed methodology to capture blood flow changes.

Citation Download Citation

Jinbin Xie M.D., Xiangdong He M.D., Zhuanping Qin, and Feng Gao "A multi-channel diffuse correlation spectroscopy system for dynamic topography of blood flow index in deep tissues", Proc. SPIE 11234, Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 112341K (21 February 2020); https://doi.org/10.1117/12.2541810

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