CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume 11257 > Article
Presentation
3 June 2020 Label-free neurophotonics: electro-plasmonic biosensors for ultrasensitive detection of electrogenic activity of cells (Conference Presentation)
Ahsan Habib, Xiangchao Zhu, Isik Uryan Can, Maverick McLanahan, Pinar Zorlutuna, Ahmet A. Yanik
Author Affiliations +
Proceedings Volume 11257, Plasmonics in Biology and Medicine XVII; 112570Q (2020) https://doi.org/10.1117/12.2546868
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
Harnessing the unprecedented spatiotemporal resolution capability of light to detect electrophysiological signals has been the goal of scientists for nearly 50 years. Advancements in this field could open new frontiers in neuroscience, cardiology and cellular biology. Yet, progress towards that goal remains elusive due to lack of electro-optic translators that can efficiently convert electrical activity to high photon-count optical signals. Here, we introduce an ultrasensitive and extremely bright nanoscale electric-field probe. Our electro-active plasmonic nanoantenna, offering ~3.25x10^3 times enhanced electric-field sensitivities than conventional plasmonic nanoantennas, overcomes the low sensitivity and photon-count limitations, and enables us to realize optical detection of electric-field dynamics with signal-to-shot-noise ratios (SSNR~ 60-220) from diffraction limited spots. We demonstrate label-free optical recording of field dynamics with sub-millisecond temporal resolution.
Conference Presentation
© (2020) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Ahsan Habib, Xiangchao Zhu, Isik Uryan Can, Maverick McLanahan, Pinar Zorlutuna, and Ahmet A. Yanik "Label-free neurophotonics: electro-plasmonic biosensors for ultrasensitive detection of electrogenic activity of cells (Conference Presentation)", Proc. SPIE 11257, Plasmonics in Biology and Medicine XVII, 112570Q (3 June 2020); https://doi.org/10.1117/12.2546868
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Near field optics
Biosensors
Nanoantennas
Neurophotonics
Plasmonics
Refractive index
Metals
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top