Optical histology for cancer detection and PDT treatment assessment

Defu Chen; David W. Nauen; Xingde Li; Ying Gu

doi:10.1117/12.2579363

10 October 2020 Optical histology for cancer detection and PDT treatment assessment

Defu Chen, David W. Nauen, Xingde Li, Ying Gu

Proceedings Volume 11553, Optics in Health Care and Biomedical Optics X; 1155318 (2020) https://doi.org/10.1117/12.2579363
Event: SPIE/COS Photonics Asia, 2020, Online Only

Abstract

High-resolution imaging technologies, such as multiphoton imaging (MPM) and optical coherence tomography (OCT), are capable of high-speed imaging of biological tissues in vivo with subcellular resolution. In brain cancer surgery, it is challenging to distinguish cancer from noncancer intraoperatively. This study shows that MPM can provide label-free images with histological details. Increased cellularity, microvascular proliferation, nuclear pleomorphism and collagen deposition, can be clearly visualized in cancerous human brain tissues. Photodynamic therapy (PDT) is an effective treatment for cancers. The change of tumor vasculatures, including a newly-formed microvascular, in response to PDT, is a key assessment parameter for optimizing the treatment effect. We demonstrated the in vivo imaging of PDT effects on mouse tumor model with an ultrahigh-resolution functional OCT. The technologies have shown significant translational potential for cancer detection and PDT treatment assessment.

Conference Presentation

Citation Download Citation

Defu Chen, David W. Nauen, Xingde Li, and Ying Gu "Optical histology for cancer detection and PDT treatment assessment", Proc. SPIE 11553, Optics in Health Care and Biomedical Optics X, 1155318 (10 October 2020); https://doi.org/10.1117/12.2579363

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