Time-gated diffuse correlation spectroscopy for functional imaging via 1064 nm pulse laser shaping and superconducting nanowire single photon sensing

Nisan Ozana; Adriano Peruch; Mitchell Robinson; Dibbyan Mazumder; Megan Blackwell; Niyom Lue; Stefan Carp; Maria Angela Franceschini

doi:10.1117/12.2578909

5 March 2021 Time-gated diffuse correlation spectroscopy for functional imaging via 1064 nm pulse laser shaping and superconducting nanowire single photon sensing

Nisan Ozana, Adriano Peruch, Mitchell Robinson, Dibbyan Mazumder, Megan Blackwell, Niyom Lue, Stefan Carp, Maria Angela Franceschini

Author Affiliations +

Proceedings Volume 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics; 116292F (2021) https://doi.org/10.1117/12.2578909
Event: SPIE BiOS, 2021, Online Only

Abstract

Recently, we developed a time-domain diffuse correlation spectroscopy (TD-DCS) method for neurovascular sensing with higher brain sensitivity. In this paper, laser pulse shaping was designed and demonstrated for TD-DCS at 1064 nm. A quantum superconducting nanowire single-photon detector (SNSPD) with high photon detection efficiency (PDE) and low jitter collects the back-scattered light from the brain. The presented approach is the first step towards scaling up a full fiber optic cap with 96 source channels and 192 custom-made single-photon detectors which will cover most of an adult head.

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Nisan Ozana, Adriano Peruch, Mitchell Robinson, Dibbyan Mazumder, Megan Blackwell, Niyom Lue, Stefan Carp, and Maria Angela Franceschini "Time-gated diffuse correlation spectroscopy for functional imaging via 1064 nm pulse laser shaping and superconducting nanowire single photon sensing", Proc. SPIE 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 116292F (5 March 2021); https://doi.org/10.1117/12.2578909

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KEYWORDS

Nanowires

Pulsed laser operation

Spectroscopy

Superconductors

Brain

Functional imaging

Imaging spectroscopy

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