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5 March 2021 Label-free quantification of oxidative stress on HS68 cells using optical diffraction tomography
Ariel J. Lee, Mahn Jae Lee, Hye-Jin Kim, WeiSun Park, YongKeun Park
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Proceedings Volume 11653, Quantitative Phase Imaging VII; 1165314 (2021) https://doi.org/10.1117/12.2584888
Event: SPIE BiOS, 2021, Online Only
Abstract
Although oxidative stress is believed to play an important role in numerous diseases, current methods of measuring the oxidative stress level do not provide a consensus on how to quantify and compare the level of oxidative stress. Here, we suggest optical diffraction tomography (ODT) as a label-free cellular oxidative stress level quantification method. ODT measurements of HS68 cells treated with hydrogen peroxide solution showed that the oxidative stress level can be quantified based on the biophysical features from the refractive index (RI) tomogram. Quantifying the cellular oxidative stress based on the RI measurements will provide a direct guideline for the level of cell stresses on both academic and clinical situations.
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Ariel J. Lee, Mahn Jae Lee, Hye-Jin Kim, WeiSun Park, and YongKeun Park "Label-free quantification of oxidative stress on HS68 cells using optical diffraction tomography", Proc. SPIE 11653, Quantitative Phase Imaging VII, 1165314 (5 March 2021); https://doi.org/10.1117/12.2584888
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KEYWORDS
Diffraction
Optical tomography
Tissue optics
Tomography
Skin
Inflammation
Luminescence
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