label-free multimodal nonlinear imaging of the treatment response in pancreatic tumor patient-derived xenografts in mice

Jaena Park; Eric Chaney; Sixian You; Amro Abdelrahman; Jennifer Leiting; Jennifer Yonkus; Peter Groves; Jonathan Harrington; Darold Spillman; Issac Lynch; Marina Marjanovic; Haohua Tu; Colleen Bushell; Heidi Nelson; Mark Truty; Stephen A. Boppart

doi:10.1117/12.2576912

5 March 2021 label-free multimodal nonlinear imaging of the treatment response in pancreatic tumor patient-derived xenografts in mice

Jaena Park, Eric Chaney, Sixian You, Amro Abdelrahman, Jennifer Leiting, Jennifer Yonkus, Peter Groves, Jonathan Harrington, Darold Spillman, Issac Lynch, Marina Marjanovic, Haohua Tu, Colleen Bushell, Heidi Nelson, Mark Truty, Stephen A. Boppart

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Proceedings Volume 11655, Label-free Biomedical Imaging and Sensing (LBIS) 2021; 116550J (2021) https://doi.org/10.1117/12.2576912
Event: SPIE BiOS, 2021, Online Only

Abstract

For investigating the potential for personalized treatment of pancreatic cancer, two- and three-photon autofluorescence and second and third harmonic generation images were simultaneously generated from in vivo pancreatic tumor patient-derived xenograft (PDX) mice. Two different treatment regimens were administered to PDX mice for 5 weeks and compared. Control mice were treated only with saline. Mice were classified into three groups according to their response to the treatment: responsive, resistant, and control. Optical redox ratios were calculated from tumor regions which showed differences between the responsive group compared to the resistant and control groups.

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Jaena Park, Eric Chaney, Sixian You, Amro Abdelrahman, Jennifer Leiting, Jennifer Yonkus, Peter Groves, Jonathan Harrington, Darold Spillman, Issac Lynch, Marina Marjanovic, Haohua Tu, Colleen Bushell, Heidi Nelson, Mark Truty, and Stephen A. Boppart "label-free multimodal nonlinear imaging of the treatment response in pancreatic tumor patient-derived xenografts in mice", Proc. SPIE 11655, Label-free Biomedical Imaging and Sensing (LBIS) 2021, 116550J (5 March 2021); https://doi.org/10.1117/12.2576912

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KEYWORDS

Tumors

Multimodal imaging

Microscopy

In vivo imaging

Pancreatic cancer

Convolution

Harmonic generation

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