Quality control of tablets "Papazol" by spectrophotometry using chemometrics

Tatiana Rusanova; Nataliya Shestopalova; Yuliya Fomina; Nataliya Burmistrova; Dmitriy Silaev

doi:10.1117/12.2590713

4 May 2021 Quality control of tablets "Papazol" by spectrophotometry using chemometrics

Tatiana Rusanova, Nataliya Shestopalova, Yuliya Fomina, Nataliya Burmistrova, Dmitriy Silaev

Author Affiliations +

Proceedings Volume 11845, Saratov Fall Meeting 2020: Optical and Nanotechnologies for Biology and Medicine; 118450Q (2021) https://doi.org/10.1117/12.2590713
Event: Saratov Fall Meeting 2020, 2020, Saratov, Russian Federation

Abstract

The dosing uniformity indicator of the «Papazol» tablets of two manufacturers was evaluated according to the Russian State Pharmacopoeia XIV and by Principal Component Analyis (РСА). The pharmacopoeial method showed that “Papazol” tablets (“Pharmstandart-Leksredstva”) satisfy the requirements for dosage uniformity. “Papazol” tablets (“Irbit Chemical Pharmaceutical Plant”) do not meet the requirements for dosing uniformity. The possibility of the PCA method application for rapid testing of “Papazol” tablets for dosage uniformity was investigated. The results obtained are consistent with the data obtained using the pharmacopoeial direct determination method. The objective of this study was to present the spectrophotometry method coupled with chemometrics approaches as a simple, cost-effective, and accurate for the dosing uniformity indicator testing in pharmaceutical formulation.

Citation Download Citation

Tatiana Rusanova, Nataliya Shestopalova, Yuliya Fomina, Nataliya Burmistrova, and Dmitriy Silaev "Quality control of tablets "Papazol" by spectrophotometry using chemometrics", Proc. SPIE 11845, Saratov Fall Meeting 2020: Optical and Nanotechnologies for Biology and Medicine, 118450Q (4 May 2021); https://doi.org/10.1117/12.2590713

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE