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Microstructured optical fibers (MOF) are a highly efficient support for the design and construction of sensitive and lowcost sensors. Currently, molecular imprinting is one of the promising method of MOF inner surface functionalization. Molecularly imprinted polymers (MIP) can be synthesized at MOF inner surface and intensify the selectivity and efficiency of target molecules sorption. This approach can be the base for selective sorption and detection of target molecules on a single sensor device. This paper describes MOF modification by MIP selective for bovine serum albumin (BSA). Polyaniline was used as matrix MIP polymer and was obtained by chemical oxidate polymerization of aniline in soft acid conditions. MOF transmission spectrum were used for monitoring of bonding between the protein molecules and MIP.
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Kirill Y. Presnyakov, Pavel S. Pidenko, Julia S. Skibina, Natalia A. Burmistrova, "Hollow core microstructured optical fibers as support for synthesis of molecularly imprinted polymers," Proc. SPIE 11845, Saratov Fall Meeting 2020: Optical and Nanotechnologies for Biology and Medicine, 118451K (4 May 2021); https://doi.org/10.1117/12.2589420