Refractive index tomography for drug-induced liver injury analysis

Juan M. Soto; Fabio A. Aguilar Mora; José A. Rodrigo; Yana Geng; Nshunge Musheshe; Manon Buist-Homan; Frank Lezoualc'h; Xiaodong Cheng; Martina Schmidt; Han Moshage; Tatiana Alieva

doi:10.1117/12.2615732

7 December 2021 Refractive index tomography for drug-induced liver injury analysis

Juan M. Soto, Fabio A. Aguilar Mora, José A. Rodrigo, Yana Geng, Nshunge Musheshe, Manon Buist-Homan, Frank Lezoualc'h, Xiaodong Cheng, Martina Schmidt, Han Moshage, Tatiana Alieva

Author Affiliations +

Proceedings Volume 11922, Advances in Microscopic Imaging III; 119220W (2021) https://doi.org/10.1117/12.2615732
Event: European Conferences on Biomedical Optics, 2021, Online Only

Abstract

Refractive index tomography compatible with conventional microscope is used for analyzing primary rat hepatocytes injury induced by pharmacological treatments. We found that mitochondria malfunctioning is correlated with refractive index variation.

Citation Download Citation

Juan M. Soto, Fabio A. Aguilar Mora, José A. Rodrigo, Yana Geng, Nshunge Musheshe, Manon Buist-Homan, Frank Lezoualc'h, Xiaodong Cheng, Martina Schmidt, Han Moshage, and Tatiana Alieva "Refractive index tomography for drug-induced liver injury analysis", Proc. SPIE 11922, Advances in Microscopic Imaging III, 119220W (7 December 2021); https://doi.org/10.1117/12.2615732

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