In Vivo longitudinal monitoring of structure, texture and angiogenesis of photothermal-therapy for melanoma and pancreatic tumor using optical coherence tomopgraphy

Feng Yan; Trisha Valerio; Mourren Sibichan; Kari Chambers; Emily Bishop; Tyler Wilson; Chen Wang; Yuyang Yan; Ashley Hoover; Wei Chen; Qinggong Tang

doi:10.1117/12.2608348

2 March 2022 In Vivo longitudinal monitoring of structure, texture and angiogenesis of photothermal-therapy for melanoma and pancreatic tumor using optical coherence tomopgraphy

Feng Yan, Trisha Valerio, Mourren Sibichan, Kari Chambers, Emily Bishop, Tyler Wilson, Chen Wang, Yuyang Yan, Ashley Hoover, Wei Chen, Qinggong Tang

Author Affiliations +

Proceedings Volume 11961, Biophotonics and Immune Responses XVII; 1196103 (2022) https://doi.org/10.1117/12.2608348
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Pancreatic tumors and melanoma are two types of cancers with high mortality. Monitoring the tumor microenvironment during growth plays an important role in studying the property of tumors. To study the progression of pancreatic tumors and melanoma in vivo, we propose to use optical coherence tomography (OCT) to monitor the tumor structure and angiogenesis in mouse in a longitudinal manner. Our results demonstrate that OCT is a promising tool to longitudinally monitor the change and progression of structure, tissue distribution, and microvasculature in pancreatic and melanoma tumor models. OCT can serve as a promising modality to provide structural and microvascular information for future anti-cancer treatment and drug development.

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Feng Yan, Trisha Valerio, Mourren Sibichan, Kari Chambers, Emily Bishop, Tyler Wilson, Chen Wang, Yuyang Yan, Ashley Hoover, Wei Chen, and Qinggong Tang "In Vivo longitudinal monitoring of structure, texture and angiogenesis of photothermal-therapy for melanoma and pancreatic tumor using optical coherence tomopgraphy", Proc. SPIE 11961, Biophotonics and Immune Responses XVII, 1196103 (2 March 2022); https://doi.org/10.1117/12.2608348

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KEYWORDS

Tumors

Optical coherence tomography

Melanoma

Signal attenuation

Tissues

Angiography

In vivo imaging

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