Mid-infrared photoacoustic microscopy by gas-filled hollow-core fiber laser

Cuiling Zhang; Kunyang Sui; Marcello Meneghetti; Jose Enrique Antonio-Lopez; Manoj K. Dasa; Rune W. Berg; Rodrigo Amezcua-Correa; Yazhou Wang; Christos Markos

doi:10.1117/12.3022104

20 June 2024 Mid-infrared photoacoustic microscopy by gas-filled hollow-core fiber laser

Cuiling Zhang, Kunyang Sui, Marcello Meneghetti, Jose Enrique Antonio-Lopez, Manoj K. Dasa, Rune W. Berg, Rodrigo Amezcua-Correa, Yazhou Wang, Christos Markos

Author Affiliations +

Proceedings Volume 13007, Neurophotonics II; 1300706 (2024) https://doi.org/10.1117/12.3022104
Event: SPIE Photonics Europe, 2024, Strasbourg, France

Conference Poster

Abstract

The emerging mid-infrared photoacoustic microscopy (MIR-PAM) is a potential imaging modality in revealing special biomolecules compositions in thick samples by utilizing the light-excited ultrasound signals. The development of a nanosecond and high-energy MIR fiber laser source is still at an early age, facing the challenges of either low peak power or large footprint. This work aims to develop a new Raman laser source for MIR-PAM based on the gas-filled anti-resonant hollow core fiber (ARHCF) technology. As a proof of concept, a MIR laser source at 3.4 μm is developed and combined with PAM for the first time targeting at the lipid-rich mouse brain sample due to main absorption band of myelin sheaths. This laser source is based on the cascading of two ARHCFs, where a high-energy (~26.5 μJ) Raman Stokes line at 1409 nm is generated through the 1st-stage nitrogen-filled ARHCF with a pump fiber laser at 1060 nm. The output Raman laser from the 1st stage ARHCF is used as a pump for the 2^nd-stage hydrogen-filled ARHCF, to generate the Raman laser at 3.4 μm with ~2.7 μJ pulse energy. Our label-free ex-vivo imaging depicted the lipid-rich myelin region in the mouse brain, showing the feasibility of extending the novel gas-filled laser platform into PAM imaging modalities.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

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Cuiling Zhang, Kunyang Sui, Marcello Meneghetti, Jose Enrique Antonio-Lopez, Manoj K. Dasa, Rune W. Berg, Rodrigo Amezcua-Correa, Yazhou Wang, and Christos Markos "Mid-infrared photoacoustic microscopy by gas-filled hollow-core fiber laser", Proc. SPIE 13007, Neurophotonics II, 1300706 (20 June 2024); https://doi.org/10.1117/12.3022104

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