Conjugated-DNA hybrid materials for biosensing imaging and therapy applications

Leilei Tian

doi:10.1117/12.3036949

30 September 2024 Conjugated-DNA hybrid materials for biosensing imaging and therapy applications

Leilei Tian

Author Affiliations +

Proceedings Volume 13124, Organic and Hybrid Sensors and Bioelectronics XVII; 1312406 (2024) https://doi.org/10.1117/12.3036949
Event: Organic Photonics + Electronics, 2024, San Diego, California, United States

Abstract

We developed an efficient solid-phase click reaction method to create π-conjugated-DNA amphiphilic molecules. Introducing hydrophilic DNA fragments improves the biocompatibility of π-conjugated materials and their recognition and response performance to bio-systems. π-Conjugated materials also provide optical signals for tracing and regulating the functions of DNA. This novel π-conjugated-DNA hybrid material system expands the application scope of π-conjugated materials in biomedicines. Specifically, my talk will include: (1) The development of π-conjugated-DNA amphiphilic molecules with reversible assembling properties provides a new design mechanism for the development of intelligent fluorescent bio-sensing materials; (2) Combining the encoding capability of DNA and the optical amplification properties of π-conjugated materials, amplified and highly multiplexed molecular imaging in single cells; (3) the application in light-gene combined therapy effectively improves the optical therapeutic effect of π-conjugated materials.

Conference Presentation

Citation Download Citation

Leilei Tian "Conjugated-DNA hybrid materials for biosensing imaging and therapy applications", Proc. SPIE 13124, Organic and Hybrid Sensors and Bioelectronics XVII, 1312406 (30 September 2024); https://doi.org/10.1117/12.3036949

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