Impact of murine skull on transcranial photoacoustic imaging: a numerical study

Feiyang Pan; Xingyu Wei; Chao Tian

doi:10.1117/12.3048489

5 December 2024 Impact of murine skull on transcranial photoacoustic imaging: a numerical study

Feiyang Pan, Xingyu Wei, Chao Tian

Proceedings Volume 13418, Fifteenth International Conference on Information Optics and Photonics (CIOP 2024); 134181P (2024) https://doi.org/10.1117/12.3048489
Event: 15th International Conference on Information Optics and Photonics (CIOP2024), 2024, Xi’an, China

Abstract

Photoacoustic Imaging (PAI) is a promising transcranial imaging technique for the mouse brain. However, the mouse skull imposes severe wavefront distortion to photoacoustic signals, thus reducing the quality of PAI. In this article, numerical simulations are implemented to study the influence of skull on PAI with respect to the distance of photoacoustic sources to skull. The k-Wave toolbox is adopted to simulate the photoacoustic wave propagation. The waveforms of shear and longitudinal waves within the skull layer are analyzed. Time reversal algorithm is applied to reconstruct the photoacoustic sources. Reconstruction results show that the mode conversion at the inner skull surface can cause streak artifacts around reconstructed point sources, and the artifacts are more obvious when the sources are near the skull. This study is expected to provide useful insights for transcranial photoacoustic imaging.

Citation Download Citation

Feiyang Pan, Xingyu Wei, and Chao Tian "Impact of murine skull on transcranial photoacoustic imaging: a numerical study", Proc. SPIE 13418, Fifteenth International Conference on Information Optics and Photonics (CIOP 2024), 134181P (5 December 2024); https://doi.org/10.1117/12.3048489

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