Artifact-free differential phase contrast quantitative phase imaging with aberration correction

Chenyue Zheng; Yao Fan; Jiasong Sun; Chao Zuo

doi:10.1117/12.3048502

5 December 2024 Artifact-free differential phase contrast quantitative phase imaging with aberration correction

Chenyue Zheng, Yao Fan, Jiasong Sun, Chao Zuo

Proceedings Volume 13418, Fifteenth International Conference on Information Optics and Photonics (CIOP 2024); 134181V (2024) https://doi.org/10.1117/12.3048502
Event: 15th International Conference on Information Optics and Photonics (CIOP2024), 2024, Xi’an, China

Abstract

Differential Phase Contrast (DPC) is a promising Quantitative Phase Imaging (QPI) technique. Typically, DPC recovers quantitative phase by acquiring four intensity images under asymmetric half-circular illumination and performing phase deconvolution. It has the advantages of being unlabeled, non-coherent, and highly robust. However, for any optical system, inevitable system defects, uneven optical properties of biological samples, and disruptions from the environment may cause aberrations, resulting in severe reconstruction artifacts in DPC. We propose an artifact-free DPC method based on simulated annealing algorithm, which combines the optimized annular illumination and aberration correction, achieving high-quality quantitative phase reconstruction. Three half-annular illuminations are used to achieve an enhanced phase transfer response over the entire spectrum bandwidth. At the same time, the three acquired intensities are used to implement phase inversion, and the aberration coefficients of the pupil are updated using simulated annealing, which achieves accurate estimation of the aberration coefficients by minimizing the difference between the acquired and estimated intensities. Simulation and experimental results show that this method can simultaneously reconstruct the object phase and system aberration with only three images, realizing artifact-free, high-resolution, and efficient QPI.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Chenyue Zheng, Yao Fan, Jiasong Sun, and Chao Zuo "Artifact-free differential phase contrast quantitative phase imaging with aberration correction", Proc. SPIE 13418, Fifteenth International Conference on Information Optics and Photonics (CIOP 2024), 134181V (5 December 2024); https://doi.org/10.1117/12.3048502

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KEYWORDS

Light sources and illumination

Phase transfer function

Pupil aberrations

Reconstruction algorithms

Algorithms

Phase reconstruction

Aberration correction

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