Kinetic models for coagulation processes: determination of rate coefficients in vivo

John Anthony Pearce; Wai-Fung Cheong; Kirit Pandit; Tom J. McMurray; Sharon L. Thomsen M.D.

doi:10.1117/12.43937

1 June 1991 Kinetic models for coagulation processes: determination of rate coefficients in vivo

John Anthony Pearce, Wai-Fung Cheong, Kirit Pandit, Tom J. McMurray, Sharon L. Thomsen M.D.

Proceedings Volume 1422, Lasers in Dermatology and Tissue Welding; (1991) https://doi.org/10.1117/12.43937
Event: Optics, Electro-Optics, and Laser Applications in Science and Engineering, 1991, Los Angeles, CA, United States

Abstract

Kinetic models of thermal damage in tissues can be used to describe histologic end points obtained with laser irradiation. In this study, thermographic measurements of skin surface temperature distributions during laser impingement were used to derive a temperature history for the lesion site. Lesions were evaluated at 48 h after laser irradiation to determine the radius of purpura formation. The temperature histories at the maximum radius of purpura formation (threshold temperatures) were analyzed and plotted on Arrhenius axes to estimate rate coefficients for the process. As expected, transient in vivo thermal history data yielded a noisy Arrhenius plot; however, estimates of the appropriate rate coefficients for purpura formation in vivo could be made.

Citation Download Citation

John Anthony Pearce, Wai-Fung Cheong, Kirit Pandit, Tom J. McMurray, and Sharon L. Thomsen M.D. "Kinetic models for coagulation processes: determination of rate coefficients in vivo", Proc. SPIE 1422, Lasers in Dermatology and Tissue Welding, (1 June 1991); https://doi.org/10.1117/12.43937

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available